Animals
C57BL/6 mice (male, 20-22g, 6-8 weeks) were purchased from Dalian Medical University (Dalian, China). NLRP3-deficient (NLRP3-/-; #0017970) mice (male, 20-22g, 6-8 weeks) and macrophage-specific CD1d deficient (CD1d-/-; #008881) mice (male, 20-22g, 6-8 weeks) were obtained from the Third Military Medical University (Department of Immunology, Chongqing, China). All mice were housed at a temperature of 20-25℃ and a relative humidity of 55%-65%, and free diet and water. All animal experiments were approved by the Animal Welfare and Ethics Committee of Dalian University (no. SCAV-EXPANIM).