This paper introduces a novel framework that leverages ontology engineering to enhance big data science, addressing challenges such as data heterogeneity, integration, and scalability. The framework employs semantic technologies to unify diverse datasets, enabling advanced knowledge representation, reasoning, and predictive modelling. By integrating ontological methods with big data analytics, the framework demonstrates improved data integration and analysis across multiple domains. Case studies in big data management and healthcare systems illustrate the practical applications and benefits of the framework, including enhanced data quality, semantic alignment, and process efficiency. This work advances the field of big data science by providing a scalable and interoperable solution for managing complex datasets, paving the way for future research and applications in data-driven domains.