Background & objectives: Nasal irrigation is a commonly used supportive treatment method for rhinosinus diseases. However, there is no consensus on how effectively irrigation should be applied to infants. The aim of the study is to examine the effects of two different nasal irrigation techniques applied to relieve nasal congestion in infants on physiological parameters and crying time. Methods: This study was randomized controlled experimental study. This study was conducted at the pediatric emergency clinic of the tertiary care hospital. Infants aged 1-12 months presenting with nasal congestion due to upper respiratory tract infections were enrolled in the study. Low-volume saline irrigation was applied to one group and high-volume saline irrigation was applied to the other group. Physiological parameters, procedure duration, procedure repetition frequency, and crying durations were evaluated before, and after the procedure. Results: In the study, the saturation of infants who received nasal irrigation with high-volume saline was found to be higher after the procedure compared to infants who received low-volume saline (p=0.000). Compared to the infants who were administered low-volume saline, the infants who received nasal irrigation with high-volume saline; respiratory rate (p=0.000), crying time and mean procedure time (p=0.000) were found to be lower after the procedure. Conclusions: As a result, in infants who received nasal irrigation with high volume saline; oxygen saturation, respiratory rate, procedure time, frequency of repetitions of the procedure and crying time are more positively affected. It is recommended to prefer high-volume nasal irrigation for infants with nasal congestion.