In March 2023, over 800 researchers, clinicians, patients, survivors, and advocates from the pediatric oncology community met to discuss the progress, plans, and future priorities of the National Cancer Institute’s Childhood Cancer Data Initiative. We present here the status of the initiative’s efforts in building its data ecosystem to provide access to childhood cancer data; updates on the Molecular Characterization Initiative; plans for implementing a Coordinated National Initiative for Rare Cancers in Children and Young Adults; and efforts to establish a framework for computable consent.