Background
Hematopoietic stem cell transplantation can be curative for children
with difficult to treat leukemia. The conditioning regimen utilised is
known to influence outcomes. We report outcomes of the conditioning
regimen used at the Alberta Children’s Hospital, consisting of busulfan
(with pharmacokinetic target of 3750μmol*min/day +/-10%) for 4 days,
higher dose (250 mg/m2) fludarabine and 400 centigray of total body
irradiation.