Conclusion
The use of a conditioning regimen for allogeneic hematopoietic cell
transplantation in children with ALL using Bu along with high dose Flu,
ATG and 400 Centigray of TBI results in outcomes comparable to standard
treatment with acceptable toxicities and significant reduction in the
dose of irradiation. Targeting the Bu dose based on pharmacokinetic
monitoring did not however improve outcomes in this cohort.