Aging and obesity are closely related, and the prevalence of obesity and metabolic diseases are rapidly increasing with an aging population worldwide. A key change in the adipose tissue during the aging process is the decline of lipolysis, and the excitation of the sympathetic nerve system is a key pathway to promote lipolysis. Previous studies have shown that the total saponins from Panax japonicus (TSPJs) can prevent obesity in mice with high-fat diet by increasing fat decomposition. In this work, we examine the regulatory effects of TSPJs on lipolysis in the aging state and explore the possible mechanisms. TSPJs can promote the excitation of sympathetic nerves by increasing the expression of tyrosine hydroxylase in the adipose tissue, which positively regulates the expression of lipases to revitalize lipolysis. The results suggest that TSPJs can help to resist aging-induced obesity and may be a potential medication for weight management.