Abstract
Colitis cystica profunda (CCP) is a rare benign disease characterized by mucus-filled cysts in the submucosa, sometimes similar to malignant tumors. Endoscopic, radiological and even histological examinations are not highly specific, which can easily lead to missed diagnosis and misdiagnosis, resulting in unnecessary radical surgical resection. In this report, we present two cases of CCP with their clinical and imaging features.