3.4.3 |Studies that include Bos d 5
The available evidence comes from eight studies providing information on the composition of Bos d 5[30-33, 35-38]. Overall, six studies showed high specificity (0.91-0.98) at different AUCs (0-1.94) with different sensitivities (0.24-0.82). In contrast, Uncuoglu[38] showed high sensitivity (1.0) and lower specificity (0.7), while Franco[35] showed lower diagnostic efficacy with sensitivity and specificity of 0.7 and 0.58, respectively.
The research conducted by Alessandri and Hawi[30, 31] has demonstrated that the diagnostic accuracy of various detection equipment can vary significantly. In Alessandri’s study[31], the sensitivity and specificity of ImmunoCAP were found to be 0.90 and 0.50, respectively. However, when the
Table 2 Summary DTA measures of CRD components tested by allergy component
ISAC test was used, the sensitivity and specificity were 0.40 and 0.94, respectively. In Hawi’s study[30], the ImmunoCAP assay, when used, showed high specificity (0.90-0.93) and low sensitivity (0.40-0.47); sensitivity was (0.65-0.78) and specificity (0.66-0.80) when using 3gAllergy assay.