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Construction of 1,3,4-oxadiazolines bearing CF3-quaternary cen-ter via amino-assisting cycloaddition of nitrile imines generated in situ with o-aminotrifluoroacetophenones
  • Yannan Zhu,
  • Jiaqing Liu,
  • Yi-Ning Wang
Yannan Zhu
Yancheng Institute of Technology
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Jiaqing Liu
Yancheng Institute of Technology
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Yi-Ning Wang
Yancheng Institute of Technology

Corresponding Author:yining.wang@ycit.cn

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Abstract

An amino-assisting [3+2] cycloaddition strategy of nitrile imines generated in situ with o-aminotrifluoroacetophenones under mild conditions has been constructed, in which a variety of 1,3,4-oxadiazolines bearing CF3-quaternary centers can be obtained in good to excellent yields. The MTT assay shows that the resulting 1,3,4-oxadiazoline derivatives could be the potential candidates for the treatments of head and neck cancers.