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Phosphine-catalyzed [4+3] annulation reaction of indole deriva-tives with MBH carbonates: A facile access to indole-1,2-fused 1,4-diazepinones and azepines
  • Yannan Zhu,
  • Haoran Jiang,
  • Yi-Ning Wang
Yannan Zhu
Yancheng Institute of Technology
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Haoran Jiang
Yancheng Institute of Technology
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Yi-Ning Wang
Yancheng Institute of Technology

Corresponding Author:yining.wang@ycit.cn

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Abstract

A phosphine-catalyzed [4+3] annulation between dinucleophilic indole derivatives and Morita−Baylis−Hillman (MBH) carbonates was discovered by using the N1 and N4′ or C4′ nucleophilicities of indole precursors, which provides an efficient and facile access to in-dole-1,2-fused 1,4-diazepinones and azepines in good to high yields in one step, in which indoles act as four atom synthons. Various transformations of products illustrate promising applications of the given protocols.
16 Aug 2023Reviewer(s) Assigned
10 Sep 2023Review(s) Completed, Editorial Evaluation Pending
18 Sep 2023Editorial Decision: Revise Minor
23 Sep 20231st Revision Received
25 Sep 2023Assigned to Editor
25 Sep 2023Submission Checks Completed
25 Sep 2023Review(s) Completed, Editorial Evaluation Pending
25 Sep 2023Editorial Decision: Accept