Experimental Approach:
This study investigated the neuroprotective effects of the
small-molecule STING inhibitor C-176 in the controlled-cortical impact
(CCI) mouse model of TBI in 10–12-week-old male mice. 30-minutes
post-CCI surgery, a single 750nmol dose of C-176 or saline (vehicle) was
administered intravenously. Analysis was conducted 2h- and 24h-post TBI.