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Accelerating the remodeling of collagen in cutaneous full-thickness wound using FIR soldering technology with bio-targeting nanocomposites hydrogel
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  • Kehong Wang,
  • Yuxin Chen,
  • Xiaopeng Li,
  • Mengyin Chen,
  • Kexin He,
  • Jun Huang,
  • Yunfeng Rui
Kehong Wang
Nanjing University of Science and Technology

Corresponding Author:wkh1602@126.com

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Yuxin Chen
Nanjing University of Science and Technology
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Xiaopeng Li
Nanjing University of Science and Technology
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Mengyin Chen
Nanjing University of Science and Technology
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Kexin He
Nanjing Medical University
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Jun Huang
Nanjing University of Science and Technology
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Yunfeng Rui
Southeast University Medical College
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Abstract

A novel composite wound dressing hydrogel by incorporating single-walled carbon nanotubes and indocyanine green into a dual-crosslinked hydrogel through Schiff base reaction was developed. The objective was to prevent wound infection and enhance the thermal effect induced by laser energy. The hydrogel matrix was constructed using oxidized gelatin, pre-crosslinked with calcium ions, along with carboxymethyl chitosan, crosslinked via Schiff base reaction. Optimization of the blank hydrogel’s gelation time, swelling index, degradation rate, and mechanical properties was achieved by adding 0.1% SWCNT and 0.1% ICG. Among them, the SWCNT-loaded hydrogel BCG-SWCNT exhibited superior performance overall: a gelation time of 102 seconds; a swelling index above 30 after equilibrium swelling; a degradation rate of 100.5% on the seventh day; and a compressive modulus of 8.8 KPa. It displayed significant inhibition against methicillin-resistant Staphylococcus aureus infection in wounds. When combined with laser energy usage, the composite hydrogel demonstrated excellent pro-healing activity in rats.
16 Oct 2023Submitted to Journal of Biophotonics
16 Oct 2023Submission Checks Completed
16 Oct 2023Assigned to Editor
16 Oct 2023Review(s) Completed, Editorial Evaluation Pending
16 Oct 2023Reviewer(s) Assigned
20 Nov 2023Editorial Decision: Revise Major