Conclusion
Conventionally, Nimesulide and Furosemide are two different groups of
drugs but an intense literature search revealed that both drugs have a
common sulfonamide functional group which triggered the subsequent
episode of TEN. Thus, it is important to note that any patient who has
had a previous hypersensitivity reaction to a drug is at high risk for
recurrence with another drug having a similar chemical structure, and
treating physicians should always consider cross-reactivity between the
chosen drugs in order to prevent the subsequent life-threatening
clinical episodes.