BACKGROUND:Arrhythmia is a common cardiac electrical phenomenon in clinic, and everyone has suffered or experienced different types of arrhythmia in different periods.In spite of the rapid development of modern medicine and the increasingly comprehensive understanding of cardiac electrophysiology, there is still no satisfactory explanation with the mechanism of some arrhythmias.There is no absolute differentiation in tissue cells of any organ, and its biological effect is based on endogenous and exogenous factors, the former is the essence and the latter is the condition.The existence or induction of certain or analogous cardiac pacemaker cells in the area of working cells may be more reasonable to explain autorhythmicity increasing in some conditions. This paper will discuss the topic.