Hepatotoxicity refers to the deterioration in liver function brought about by pharmacological chemical side effects. Hepatotoxicity is frequently brought on by a wide range of pharmaceutical drugs and environmental pollutants. Hepatotoxins are the substance that harms the liver. Hepatotoxic drugs and chemicals have the potential to damage the liver through several mechanisms, including mitochondrial dysfunction, causing the death of the liver cells, and disrupting liver metabolism. Some hepatotoxic drugs and chemicals, such as carbon tetrachloride, paracetamol, mercury, cadmium, erythromycin, ranitidine, etc causing hepatic damage by different ways. Hepatotoxicity is steadily rising in occurrence and is becoming a major cause of death on a global scale. Although there are numerous allopathic and traditional therapies that provide hepatoprotection, treating chronic liver disease remains difficult for medical practitioners. Rodents are frequently employed in the lab for inducing hepatotoxicity for this reason. Hepatic toxicity is typically induced by non-invasive techniques such as high-fat diets, alcohol, radiation, toxic medications (NSAIDs, antibiotics, and chemotherapeutic treatments), harmful metals (mercury, arsenic, lead, and cadmium), and harmful substances (CCL4, thioacetamide, aflatoxin B1, etc.).Portal vein ligation and bile duct ligation are two common invasive procedures.