Background: Intracardiac echocardiography (ICE) has been widely used in clinical and has achieved significant effects in helping control the burden of cardiovascular diseases. This study aims to conduct a bibliometric analysis of publications related to ICE and provide reference and guidance for researchers to conduct in-depth research and future topic selection in this field. Methods: In the study, a systematic search of the published research on ICE spanning the years 2000 through 2022 was carried out by us using the Science Citation Index Expanded (SCIE) and the Social Science Citation Index (SSCI) of the Web of Science. We employed various software such as VOSviewer, CiteSpace, and Bibliometrix Package to analyze publication distribution, annual trends, keyword co-occurrence, and collaboration between researchers, nations, and institutions. Results: We manually screened 1021 publications. Notwithstanding the annual number of ICE-related publications’ slight fluctuations over the previous two decades, yearly publications have increased from 8 in 2000 to 47 in 2022. The United States accounted for the most significant proportion of all publications (547) and total citations (16,017). Mayo Clinic is the most active institution, Natale Andrea is the leading scholar, and the Journal of Cardiovascular Electrophysiology published the most publications in this area. “Radiofrequency ablation” was the greatest commonly occurrences keyword. Conclusions: In the past few years, the quantity of publications related to ICE has significantly increased. Future research in ICE will focus on the diagnosis, evaluation, and treatment of structural cardiac disease and cardiomyopathy.