Biodiversity plays important roles in driving plant community dynamics and functioning. The relationship between biodiversity and ecosystem functioning is currently one of the important principles for plant management to control desertification. Replanting is required in the management of the Kubuqi Desert. However, due to the high water consumption of the vegetation planted during previous desertification control programmes, as well as the poor economic performance of these vegetations, improved practices are required for the Kubuqi Desert. We conducted mixed planting and intercropping experiments with plant species that were selected on the basis of their drought tolerance and high economic value. The results showed that mixed plant and intercropping communities could improve the ability of windbreak and sand fixation. At the same time, effective plant combinations can produce more biomass to feed livestock. We designed the best possible mixtures combining ecological benefits with economic benefits. Through this study, we provide a new method for desertification control in the Kubuqi Desert, and hope to promote the long-term effectiveness and stability of desert control.