Hybrid Nano fluids (H.N.F.s) are crucial in engineering, biomedical and industrial applications due to their high effective thermal conductivity when compared to ordinary fluid and Nano fluid (N.F).The study of hybrid Nano fluids (Cu and Al 2O 3) has a good application in blood flow through an artery. The impact of flow elements on velocity, temperature and concentrations has been discussed through graphs and values are tabulated. Copper and aluminum oxide comprises a hybrid combination; their volume fractions ranging from 0.01 to 0.2. The flow control equations were simplified before being coded and solved using Maple software. Figures show the study’s key conclusions, including the impact of several physical factors. With the aid of Tables and Figures, the holds of physical parameters on the flow distributions are demonstrated. In order to research the heat and mass phenomena caused by the Dufour and Soret effect, water is utilized as the base fluid and the hybrid nanoparticle of copper and alumina as the study material. The Soret factor affects surface thermal efficiency, but the Dufour effect limits surface mass transfer.