Inflammation is a protective response from our body to an injury in the form of five cardinal signs. It is divided into acute and chronic.Additionally, practically every autoimmune disease, from gout to inflammatory bowel disease, has it as one of the primary causes. For reducing inflammation steroidal as well as non-steroidal anti-inflammatory drugs are used. There are three important types of inflammatory mediators. In this review, we will discuss inflammation, drugs and their mechanism and some inflammatory diseases.