Research progress in the detection of common foodborne hazardous
substances based on functional nucleic acid biosensors
Abstract
With the further improvement of food safety requirements, the
development of fast, high sensitivity, and portability methods for the
determination of foodborne hazardous substances has become a new trend
in the food industry. In recent years, biosensors and platforms based on
functional nucleic acids and a range of signal amplification devices and
methods have been established to allow rapid and sensitive determination
of specific substances in samples by different methods, opening up a new
avenue of analysis and detection. In this paper, functional nucleic acid
types including aptamers, deoxyribozymes and G-quadruplexes which are
commonly used in the detection of food source pollutants are mainly
introduced, as well as nano signal amplification elements including
quantum dots, noble metal nanoparticles, magnetic nanoparticles, DNA
walkers, DNA logic gates. signal amplification technologies including
nucleic acid isothermal amplification, HCR, CHA, biological barcode, and
microfluidic system are combined with functional nucleic acid sensors
and applied to the detection of many foodborne hazardous substances,
such as foodborne pathogens, mycotoxins, residual antibiotics, residual
pesticides, industrial pollutants, heavy metals, and allergens.Finally,
the potential opportunities and broad prospects of functional nucleic
acid biosensors in the field of food analysis are discussed.
