3.3.2 Possible ferroptosis biomarkers in Hypertension
It has been mentioned above that PTGS2 may be a potential biomarker of
iron death in AIS and AS, and PTGS2 encodes COX-2. COX-2 has been
implicated in increased vascular hardness and extracellular matrix
deposition, increased vasoconstriction response, endothelial
dysfunction, and vascular inflammation. Reduction of COX-2 can reduce
vasoconstriction response and endothelial dysfunction, and reduce the
increase in vascular hardness in hypertensive
animals93. It was found that high hydrostatic pressure
induced iron death in VSMC, accompanied by up-regulation of
COX-27. Reducing COX-2 expression can improve
endothelial function and slow the progression of
hypertension94. In conclusion, it is suggested that
COX-2 may be a biomarker of ferroptosis in hypertension, which can be
proved by more studies in the future.