3.2 Ferroptosis and atrial fibrillation
Atrial fibrillation (AF) is an important risk factor for AIS, resulting in a five-fold increased risk of stroke and two-fold increased mortality77. Atrial fibrillation (AF) is also one of the most common preventable causes of AIS and is often associated with cardiogenic stroke. Compared with other ischemic stroke subtypes, cardiogenic stroke is associated with more severe severity, poorer prognosis, and a relatively higher recurrence rate78. Therefore, understanding the pathogenesis of atrial fibrillation and selecting appropriate drugs based on the pathological mechanism may greatly help the treatment and prognosis of patients with cardiogenic stroke.