3.3 Ferroptosis and hypertension
Hypertension is one of the risk factors for cardiovascular and
cerebrovascular diseases such as atherosclerosis and ischemic stroke.
Its pathophysiological mechanism is mainly related to increased vascular
resistance, manifested by endothelial dysfunction, increased
vasoconstriction, and arterial remodeling. In recent years, more and
more studies have found that ferroptosis is closely related to the
occurrence and development of hypertension7,89.
Therefore, understanding the specific relationship between ferroptosis
and hypertension will be of great benefit to the treatment of
hypertension and the prevention of cerebrovascular disease complications
caused by hypertension.