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Amit Bhalla
Amit Bhalla

Public Documents 2
Faropenem, a stable and orally bioavailable β-lactam, to counteract resistant pathoge...
Amit Bhalla

Amit Bhalla

May 29, 2023
Antimicrobial resistance is a huge challenge for the effective prevention and treatment of infectious diseases worldwide. Community-onset infections with Extended-spectrum β-lactamases (ESBL) producing bacteria are a challenge. In various studies, ESBL-producing isolates were consistently susceptible only to carbapenems. When treatment with other antibiotics fails, carbapenems are used as the last-line antibiotics for treating severe and/or resistant bacterial infections. In this narrative review, we aim to present the pharmacology of Faropenem, which is an orally administered penem antibiotic with a broad-spectrum activity against many Gram-positive and Gram-negative aerobes, and anaerobes. Faropenem is effective in the treatment of uncomplicated cystitis and is a potential solution to combat the emergence of resistance among respiratory tract pathogens. It is an alternative to fluoroquinolones or macrolides/ketolides when there is a concern with resistant pathogens. Keywords: β-lactamases, Carbapenems, Faropenem.
Oral Liposomal Iron: A promising new strategy for anemia management in clinical pract...
Amit Bhalla

Amit Bhalla

May 30, 2023
Anemia is a public health problem affecting about a third of the world's population, the major cause of it being iron deficiency. The many oral iron preparations available at present, are inadequate due to intolerance, or contraindications. IV iron preparations are painful, require patient monitoring and carry the risk of anaphylaxis. Iron salts like Iron pyrophosphate are covered with liposome, a spherical structure of a phospholipidic nature that is similar to those human cell membranes. The bioavailability of liposomal pyrophosphate iron is 3.5 times greater than the free pyrophosphate iron, 2.7 times higher than iron sulfate, and 4.1 times higher compared with iron gluconate. Clinical studies showed that oral liposomal iron is a safe and efficacious alternative to correct anaemia, as also it is a viable treatment option for iron deficiency anaemia in pregnant women.

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