The rotating packed bed (RPB) is a typical equipment in chemical process intensification technology due to its excellent mass transfer performance. In this paper，three different single-phase wire screen packing pressure drop models coupled with the interfacial area model were used to construct resistance calculation methods for porous media, respectively. The results show that simulation deviations of the liquid holdup and the pressure drop of the m-K model range from 0.92% to 27.61% and 1.63% to 34.59%, respectively. The m-K model has the highest prediction accuracy at N=500~1500 rpm. At N=2000~2500 rpm, the B model has the highest prediction accuracy. The higher the viscosity of the liquid, the more uniform the axial liquid distribution in the packing, and the longer the liquid mean residence time. The impact of different nozzle designs on liquid distribution has been investigated using a new method based on user-defined functions (UDFs).