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Simulation study of three new quadrupole ion funnels to improve low-mass ion transmission
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  • Chaohui Qiu,
  • Xiaolong Li,
  • Zhe Li,
  • Liu Yang,
  • Weimin Wang,
  • Fuxing Xu,
  • Chuanfan Ding
Chaohui Qiu
Ningbo University School of Materials Science and Chemical Engineering
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Xiaolong Li
Ningbo University School of Materials Science and Chemical Engineering
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Zhe Li
Ningbo University School of Materials Science and Chemical Engineering
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Liu Yang
Ningbo University School of Materials Science and Chemical Engineering
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Weimin Wang
Ningbo University School of Materials Science and Chemical Engineering
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Fuxing Xu
Ningbo University School of Materials Science and Chemical Engineering

Corresponding Author:xufuxing@nbu.edu.cn

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Chuanfan Ding
Ningbo University School of Materials Science and Chemical Engineering
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Abstract

Rationale: By applying RF (radio frequency) and DC (direct current) voltages to corresponding ring electrodes, ion funnel (IF) can efficiently focus and transmit ions. However, IF has an inherent mass discrimination problem that will greatly limit ion focusing and transmission. In order to improve the transmission efficiency (TE) of the IF and remove this limitation, this paper explores the new quadrupole ion funnel (QIF). Methods: Computer simulations of the potential field distributions of QIF and conventional IF were performed to assess their focusing characteristics. To compare the TE, using the ion optics simulation programmes SIMION and AXSIM, a series of simulations were carried out. Toroidal, cylindrical and hyperbolic configurations are used to improve ion TE. And compare transmission and focus performance with conventional IF. Results: By simulating the trajectories of low m/z ions in the IF with SIMION and AXISM software, in this paper, the optimum electrical parameters for three new QIFs are obtained, and compared them with the conventional IF, which can improve the TE of m/z < 100 by about 16%, 20% and 13%, respectively. Conclusions: The results indicate that the study of these three new configuration IF has great research significance for improving the sensitivity of low m/z ions in mass spectrometer instruments.
10 May 2023Submitted to Rapid Communications in Mass Spectrometry
12 May 2023Submission Checks Completed
12 May 2023Assigned to Editor
12 May 2023Review(s) Completed, Editorial Evaluation Pending
12 May 2023Reviewer(s) Assigned
27 Jun 2023Editorial Decision: Revise Major
22 Jul 20231st Revision Received
25 Jul 2023Assigned to Editor
25 Jul 2023Submission Checks Completed
25 Jul 2023Review(s) Completed, Editorial Evaluation Pending
28 Jul 2023Reviewer(s) Assigned
30 Aug 2023Editorial Decision: Revise Major
13 Sep 20232nd Revision Received
13 Sep 2023Assigned to Editor
13 Sep 2023Submission Checks Completed
13 Sep 2023Review(s) Completed, Editorial Evaluation Pending
15 Sep 2023Editorial Decision: Accept