Objective: To evaluate changes in multimodal retinal imaging of patients with chronic myeloid leukemia. Methods: Observational case series study. All patients underwent a complete ophthalmic examination and were imaged with multimodal imaging before and after therapy for CML. Results: Mean age at diagnosis was 15 years old. All patients were male. The retinal findings at diagnosis were foveal infiltrates in 66.6%, retinal infiltration in 66.6%, venous dilation and arterial tortuosity in 66.6%, retinal hemorrhages in 100%, pre-retinal hemorrhages 33.3%, cotton-wool spots in 66.6%, Roth’s spots in 100%. Mean follow-up was 94.6 weeks (range 20-150 weeks). Regression of LR was completed after 100 days (range 56-170 days), and regression of macular infiltrates, at day 19 (range 17-21 days). Conclusion: MRI can provide relevant information when monitoring clinical response for systemic conditions affecting the eyes. At first, foveal infiltrates tend to disappear once the induction therapy has started. Retinal hemorrhages, vascular dilation, retinal infiltrates, and cotton wool spots tend to gradually disappear associated to the reduction of mature cells into the blood stream and the achievement of a major molecular response (MMR) assessed by TR-PCR.