Monkeypox (Mpox) is a re-emerging zoonotic disease caused by Monkeypox virus. Several countries in the world have been reported Mpox outbreak recently besides West and Central Africa where it is an endemic disease which is a warning signal and it becomes a global public health concern. The infection can be transmitted from one infected person or animal to another. Fever, rash and lymphadenitis are the most common symptoms. Smallpox vaccines can be used for prevention of Mpox along with general measures. This review article covers the epidemiology, current outbreak and preventive measures of Mpox.