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Slowing of EEG waves correlates with striatal [18F]fluorodopa PET/CT uptake and executive dysfunction in Parkinson’s disease
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  • Karolina Lorek,
  • Joanna Mączewska,
  • Leszek Królicki,
  • Magdalena Siemiatycka,
  • Małgorzata Chalimoniuk,
  • Katarzyna Kisiel-Sajewicz,
  • Jarosław Marusiak
Karolina Lorek
Wroclaw University of Health and Sport Sciences

Corresponding Author:karolina.lorek@awf.wroc.pl

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Joanna Mączewska
Medical University of Warsaw
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Leszek Królicki
Medical University of Warsaw
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Magdalena Siemiatycka
Wroclaw University of Health and Sport Science
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Małgorzata Chalimoniuk
Józef Piłsudski University of Physical Education in Warsaw
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Katarzyna Kisiel-Sajewicz
Wroclaw University of Health and Sport Science
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Jarosław Marusiak
Wroclaw University of Health and Sport Science
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Abstract

Multimodal studies evaluating associations between specific for Parkinson’s disease (PD) neuroimaging and neurophysiological biomarkers in revealing executive dysfunction mechanisms are scarce and needed to be validated. Hence, our study aimed to evaluate associations between electroencephalographic power spectral density (PSD-EEG), striatal [18F]Fluorodopa uptake and neuropsychological testing parameters in PD. Additional aim was to estimate PD diagnostic accuracy of the PSD-EEG parameters. We compared resting PSD-EEG, striatal [18F]Fluorodopa uptake ratio with positron emission computed tomography ([18F]FDOPA PET/CT), and neuropsychological test outcomes between PD patients and healthy controls, and then calculated correlations among these outcomes. Additionally we estimated PD diagnostic sensitivity and specificity (with the receiver operating characteristic curves) of the PSD-EEG parameters in reference to the gold diagnostic standard of the striatal [18F]FDOPA PET/CT uptake ratio.PD patients exhibited (i) increased power of the EEG theta and lower-alpha bands in the frontal lobe areas, (ii) decreased putaminal and caudate nuclei [18F]FDOPA PET/CT uptake ratios and (iii) longer performance times of part A and B of the Trail Making Test (TMT-A and TMT-B). Most of the PSD-EEG parameters negatively correlated with striatal [18F]FDOPA PET/CT uptake ratios and positively correlated with TMT-A and TMT-B. Furthermore, [18F]FDOPA PET/CT uptake ratios positively correlated with TMT-A and TMT-B. Theta and lower-alpha bands PSD-EEG were found to have high diagnostic accuracy. Our findings showed that slowing of EEG waves in the frontal lobe was correlated with striatal dopaminergic deficiency and executive dysfunction in mild PD patients, and appears to be a promising biomarker of PD-related executive dysfunction.
04 May 2023Submitted to European Journal of Neuroscience
05 May 2023Submission Checks Completed
05 May 2023Assigned to Editor
06 May 2023Review(s) Completed, Editorial Evaluation Pending
07 May 2023Reviewer(s) Assigned
23 May 2023Editorial Decision: Revise Major
30 Aug 20231st Revision Received
02 Sep 2023Submission Checks Completed
02 Sep 2023Assigned to Editor
02 Sep 2023Review(s) Completed, Editorial Evaluation Pending
02 Sep 2023Reviewer(s) Assigned
14 Sep 2023Editorial Decision: Accept