Self-powered sensors have emerged as a promising solution to this challenge, offering a range of benefits such as low cost, high stability, and environmental friendliness. One of the most promising self-powered sensor technologies is L-S TENG, which stands for the liquid-solid triboelectric nanogenerator. In this review paper, the working principle with three basic modes has been briefly introduced firstly. After that, affecting parameters to L-S TENG are reviewed based on the properties of the liquid and solid phases. With different working principles, L-S TENG has designed a lot of structure that works as self-powered sensor for pressure/force change, liquid flow motion, concentration, and chemical detection or biochemical sensing. On the other hand, the continuous output signal of TENG plays an important role in a real-time sensor which is extremely necessary for the development of the Internet of Things.