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Calcium iodide mediated coupling of complex fluorooligosaccharides to phenolic peptide
  • +3
  • Pei Liu,
  • Xing Quan,
  • Fangyu Wei,
  • Xianjun Deng,
  • Jie Shen,
  • Jiansong Cheng
Pei Liu
Nankai University
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Xing Quan
Nankai University
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Fangyu Wei
Nankai University
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Xianjun Deng
Nankai University
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Jie Shen
Nankai University
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Jiansong Cheng
Nankai University

Corresponding Author:jiansongcheng@nankai.edu.cn

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Abstract

Besides serving as therapeutic agents and building blocks for glycoprotein synthesis, homogeneous synthetic glycopeptides also benefit understanding function of specific glycoform. However, the selectivity coupling of oligosaccharides to a given peptide remains challenging despite the fact that the synthesis of structure-defined complex oligosaccharides has been greatly facilitated by chemoenzymatic based approaches. Herein, a Ca2+-promoted glycosylation approach was developed to exclusively modify phenolic peptide using a panel of biologically important glycans.
19 May 20231st Revision Received
19 May 2023Submission Checks Completed
19 May 2023Assigned to Editor
19 May 2023Review(s) Completed, Editorial Evaluation Pending
19 May 2023Editorial Decision: Accept