Figure 2. Differentially expressed genes (DEG) in CD4 T cells from Srsf1-ko mice overlap with genes aberrantly expressed in CD4 T cells from patients with SLE.
A . Graph shows numbers of DEGs in effector CD4 T cells from Srsf1-ko mice compared to control mice. B. Publicly available gene expression datasets from CD4 T cells from patients with SLE were curated from NCBI GEO and literature search. Graph shows cumulative numbers of DEG in SLE patients compared to healthy individuals from five datasets. C. Venn diagram shows numbers of overlapping genes between Srsf1 -ko mice and SLE patients. D. Graph shows relationship between adjusted p value and log2fold expression of overlapping genes with p<0.05.