Carbon-Hydrogen-Oxygen Symbiosis Networks (CHOSYNs) enable the centralized use of major atoms among substances.Previous decision-making in CHOSYNs researches always neglect the perspectives of multi-stakeholder, who have a claim on the cash flow of projects and may affect the sustainable operations of CHOSYNs. Hence, this paper proposes a system framework with the Multi-stakeholder decision method to balance the conflicts between stakeholders in the development of a CHOSYN. Multi-stakeholder decision method, which considers the benefits of each stakeholder, can gain a high satisfaction solution by using the dissatisfaction percentage (%D) and weight (ω). First, baseline the sources to get candidates by the multi-scale atomic targeting method. Then the simple objective and the multi-objective optimization method are used to obtain the Utopian point and the Nadir point respectively. Finally, the Multi-stakeholder decision method is used to select the optimal solution. A case study is solved to exhibit the advantages of the framewor