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Evaluation of renal markers and liver enzymes in patients infected with the Chikungunya virus
  • +3
  • Anderson Pereira Soares,
  • Daniel Ferreira de Lima Neto,
  • Marielton dos Passos Cunha,
  • Shahab Zaki Pour,
  • Saulo Passos,
  • Paolo Zanotto
Anderson Pereira Soares
Universidade de Sao Paulo Departamento de Microbiologia
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Daniel Ferreira de Lima Neto
Universidade de Sao Paulo Departamento de Microbiologia
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Marielton dos Passos Cunha
Universidade de Sao Paulo Departamento de Microbiologia
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Shahab Zaki Pour
Universidade de Sao Paulo Departamento de Microbiologia
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Saulo Passos
Faculdade de Medicina de Jundiai
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Paolo Zanotto
Universidade de Sao Paulo Departamento de Microbiologia

Corresponding Author:pzanotto@usp.br

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Abstract

Chikungunya virus (CHIKV) is an arbovirus ( Togaviridae family, Alphavirus genus), first identified in 1953 in Tanzania. In 2005, CHIKV emerged in India, and later caused outbreaks in Southeast Asia, Oceania and the Americas. Some Clinical signs are associated with CHIKV infection include fever and/or concomitant arthralgia, neurological manifestations and death. However, in infections caused by other arboviruses, such as the Dengue virus and West Nile virus, its often observed changes in liver enzymes. This study aims to evaluate the profile of the biochemical markers for kidney and liver injury patients infected with CHIKV in acute phase of infection. We found a significant elevation on the levels of creatinine in CHIKV-infected people, possibly associated with myalgia and indicative of muscle damage. The novelty was the elevated levels of creatinine found during a long period.
22 Apr 2023Submitted to Journal of Medical Virology
24 Apr 2023Submission Checks Completed
24 Apr 2023Assigned to Editor
24 Apr 2023Review(s) Completed, Editorial Evaluation Pending
11 May 2023Reviewer(s) Assigned
02 Jun 2023Editorial Decision: Revise Major
04 Sep 20231st Revision Received
06 Sep 2023Submission Checks Completed
06 Sep 2023Review(s) Completed, Editorial Evaluation Pending
06 Sep 2023Assigned to Editor
14 Sep 2023Reviewer(s) Assigned
02 Oct 2023Editorial Decision: Revise Minor
03 Nov 20232nd Revision Received
07 Nov 2023Submission Checks Completed
07 Nov 2023Assigned to Editor
07 Nov 2023Review(s) Completed, Editorial Evaluation Pending
17 Nov 2023Editorial Decision: Accept