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Emergence and high prevalence of unusual rotavirus G8P[8] strains in outpatients with acute gastroenteritis in Shanghai, China
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  • Huaqing Zhong,
  • Ran Jia,
  • Menghua Xu,
  • Pengcheng Liu,
  • Liyun Su,
  • Lingfeng Cao,
  • Xunhua Zhu,
  • Lijuan Lu,
  • Jin Xu
Huaqing Zhong
Children's Hospital of Fudan University
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Ran Jia
Children's Hospital of Fudan University
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Menghua Xu
Children's Hospital of Fudan University
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Pengcheng Liu
Children's Hospital of Fudan University
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Liyun Su
Children's Hospital of Fudan University
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Lingfeng Cao
Children's Hospital of Fudan University
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Xunhua Zhu
Children's Hospital of Fudan University
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Lijuan Lu
Children's Hospital of Fudan University
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Jin Xu
Children's Hospital of Fudan University

Corresponding Author:jinxu_125@163.com

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Abstract

Group A rotavirus (RVA) is considered an important cause of acute gastroenteritis (AGE) in all age groups, especially in children. We investigated the epidemiology of RVA in outpatients aged ≤16 years at the Children’s Hospital of Fudan University, Shanghai, China. In this study, 16.6% (246/1482) were infected with RVA. The detection rate of RVA was significantly higher in the year of 2021 (20.3%, 147/725) compared to the year of 2020 (14.5%, 77/531) and 2022 (9.7%, 22/226) ( p=0.000). RVA infection was prevalent in all seasons from 2020 to 2022, with a different monthly distribution observed in different years. Among 246 RVA-positive samples, 14 different RVA genotypes were detected with different frequencies. Overall, G9P[8] (45.5%, 112/246) was the most common RVA genotype, followed by G8P[8] (37.4%, 92/246) and G3P[8] (4.1%, 10/246). The prevalence of G/P combinations varied from 2020 to 2022. G9P[8] was the most circulating genotype in 2020 (68.2%, 15/22) and 2021 (57.8%, 85/147). However, G8P[8] (68.8%, 53/77) suddenly became the most prevalent genotype in 2022 after being first identified in 2020 and prevalent in 2021. The G8 strains detected in the study were all clustered to DS-1-like G8 strains with the closest genetic distance to strains circulating in Southeast Asia. Our study demonstrated the diversity of circulating RVA genotypes in Shanghai. The sudden emergence and high prevalence of unusual G8P[8] strains deserve more concern and indicate the need for continuous surveillance of RVA in children with AGE in the future to refine future vaccine strategy.
29 Jun 2023Submitted to Journal of Medical Virology
05 Jul 2023Submission Checks Completed
05 Jul 2023Assigned to Editor
05 Jul 2023Review(s) Completed, Editorial Evaluation Pending
14 Jul 2023Reviewer(s) Assigned
18 Aug 2023Editorial Decision: Revise Major
29 Oct 20231st Revision Received
31 Oct 2023Submission Checks Completed
31 Oct 2023Assigned to Editor
31 Oct 2023Review(s) Completed, Editorial Evaluation Pending
02 Nov 2023Reviewer(s) Assigned
18 Nov 2023Editorial Decision: Revise Minor