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\title{Science AMA Series: I'm Dr. Henry Mahncke, neuroscientist and CEO, here
today to talk about brain training, and the recent independent research
showing that our specific type of brain training can significantly
reduce the risk of dementia. AMA!}



\author[1]{socialprimate }%
\author[1]{r/Science AMAs}%
\affil[1]{Affiliation not available}%


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  \date{April 23, 2026}


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\begin{abstract}
First and foremost, full disclosure: I am the CEO of Posit Science,
which is a company that develops BrainHQ, a brain training program. I
joined Posit Science at its inception because I believed it was
essential to form a company to help the basic science of brain
plasticity become an applied science that could improve human lives. I
am also a neuroscientist by training, earning my Ph.D. from UCSF in the
lab of recent Kavli Prize Laureate Dr. Michael Merzenich, who was (and
still is!) a pioneer in the discovery and characterization of adult
brain plasticity. You may have seen his recent AMA here. Today, join me
to talk about a recent paper -- hot off the (digital) press -- showing
that speed of processing training -- a specific type of brain training
-- uniquely and significantly reduces the risk of healthy adults going
on to dementia. This is the first randomized controlled trial of any
intervention -- pharmaceutical, physical exercise, mindfulness, or
nutrition -- to show an effect on the risk of dementia. These results
come from the ACTIVE study, an NIH-funded multi-site trial, and is
authored by independent researchers, including Drs. Jerri Edwards and
Fred Unverzagt from the University of South Florida and Indiana
University. I've worked with both Dr. Edwards and Dr. Unverzagt, and I'm
very familiar with the ACTIVE study in general and these results in
particular. Check out the paper here and ask me anything! About the
ACTIVE study, dementia, the field of brain training as a whole, what
near transfer/far transfer/generalization really means, my favorite
aspects of clinical trial design and analysis (handling missing data, of
course), brain plasticity, and video games. Or take a left turn and ask
me about being ranked silver in Overwatch (the struggle is real), your
and my favorite vermouths and amari, what it's like to go from academia
to the private sector, and the best burrito in San Francisco. Proof
Edit: Hi folks - thanks for all the great questions about brain training
- how it works, what's been shown, and who it can help. It was really
fun to talk about these issues with you. I'll keep an eye on the AMA for
the rest of today and tomorrow, and answer any further questions that
get posted.%
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