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\title{Science AMA Series: I'm UCLA Prof. Tim O'Sullivan, I Investigate how the
immune system reacts to Cancer, Viral Infection, and Obesity. Ask Me
Almost Anything!}



\author[1]{TimothyOSullivan }%
\author[1]{r/Science AMAs}%
\affil[1]{Affiliation not available}%


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  \date{April 23, 2026}


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\begin{abstract}
Hi Reddit, The mammalian immune system is fascinatingly complex. Our
understanding of how the immune system recognizes and responds to
foreign pathogens has increased tremendously in the last 100 years,
however, we still have a great deal to discover. This point is
highlighted by the recent discovery of a heterogenous family of
tissue-resident lymphocytes (white blood cells) called innate
lymphocytes (ILCs), which have been reported to regulate fundamental
processes such as host metabolism, wound healing, and host defense.
Given the importance of ILCs in these processes, my research focuses on
the molecular and cellular signals that activate and sustain certain
types of ILCs (Group 1 ILCs) in specific contexts. Understanding these
mechanisms could have implications for the treatment of cancer, viral
infection, and type II diabetes. While research from the past few
decades has revealed that the immune system bridges virtually all
physiological systems as a central regulator of host homeostasis, the
general public (as well as scientists in other fields) only have vague
ideas about immune function. Specialized jargon rampant in the field
represents a barrier for the understanding of important advances in
immunology, and for public consensus on its translation to the clinic
(e.g. vaccination). Therefore, Immunologists need to make their work
more accessible by presenting it in public forums and communicating
their studies in a clear manner to try and eliminate these barriers. I
think that Reddit AMAs present an excellent opportunity to highlight
exciting findings in Immunology, and demystify academic science through
informed discussion! I am happy to answer questions about the immune
system, innate lymphocytes, and the implications for tissue-resident
immunity in health and disease. I'm also happy to answer any questions
about our most recent work
http://www.cell.com/cell/fulltext/S0092-8674(17)31183-2. Edit 1: Hi all!
I'll start answering questions at 3pm ET!! Edit 2: Thanks again everyone
for your excellent questions! Hopefully I have satisfactorily answered
them. I'm signing off for now, but if you have further questions you can
contact me through www.osullivanlab.com%
\end{abstract}%



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