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\title{Science AMA Series: I'm Andrey Rzhetsky, professor at the University of
Chicago. I study big datasets---like 150 million patient records to find
links between autism and environment, or all of PubMed to find diseases
that we should be investing more resources in. AMA!}



\author[1]{Andrey_Rzhetsky }%
\author[1]{r/Science AMAs}%
\affil[1]{Affiliation not available}%


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  \date{April 24, 2026}


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\begin{abstract}
Hi Reddit, My name is Andrey Rzhetsky, professor of medicine and
director of the Conte Center for Computational Neuropsychiatric Genomics
at the University of Chicago. I'm interested in how genetic and
environmental factors combine to make people sick. To study this, I use
mathematical modeling to look for insights in very large collections of
data. For example, I've analyzed 150 million U.S. electronic medical
records (all anonymous, of course) to examine the links between autism
and environment. We found hotspots across the U.S., which we hope will
give us insight into causes and prevention. We are now looking at
specific environmental factors that might have correlations to autism,
as well as in other diseases like bipolar disorder. We also apply
large-scale data modeling to other topics. For example, my colleagues
and I recently text-mined all of PubMed to identify research strategies
that might maximize scientific discovery and return on public
investment. You can read about some examples of our work here:
http://www.cbsnews.com/news/more-evidence-environmental-exposures-contribute-to-autism/
http://sciencelife.uchospitals.edu/2015/09/15/improving-the-allocation-of-biomedical-research-resources-with-big-data/
http://www.ci.uchicago.edu/press-releases/scientific-research-conservative-could-be-accelerated
Thank you very much for wonderful questions. Apologies for not answering
all of them! I have to go now, but thanks Reddit, it's been a lot of
fun!!''%
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