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\title{Science AMA series: We're Thomas Bartlett and Benjamin Bratton from
Princeton University. The bacterium that causes cholera is curved.
People have known this for 160 years, but never known how or why it's
curved. We figured it out\ldots{} Ask us anything!}



\author[1]{Gitai_Lab }%
\author[1]{r/Science AMAs}%
\affil[1]{Affiliation not available}%


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  \date{April 24, 2026}


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\begin{abstract}
The first observations made about most bacteria include a description of
their cell shape. Only recently have we started to figure out how all of
these different shapes arise, and to understand their purpose. Vibrio
cholerae, the bacterium that causes the deadly epidemic disease cholera,
is curved. We've known this since its discovery 160+ years ago, but
never figured out how or why. Aside from the basic research angle (how
does something so small self-organize into a complicated shape?) this
question has serious human health implications -- the world is currently
gripped by a global cholera pandemic, infecting millions and killing
over 100,000 annually. We are Thomas Bartlett (graduate student/PhD
candidate, bacterial cell biologist) and Benjamin Bratton (postdoc,
biophysicist and quantitative biologist), and we discovered the gene
(and protein) necessary for V. cholerae curvature, CrvA (for curvature
regulator in vibrio A). We found that CrvA curves the cell by causing
one side of the cell to grow faster than the other, and developed some
new tools/took some cool pictures along the way. We also found that
curvature helps V. cholerae to swim in gels, as well as to colonize and
pathogenize the host gut. Our paper just came out on Thursday, January
12th, in the journal Cell. We will be back at 3 pm ET to answer your
questions, Ask us anything! Here is a write-up of our research! - A
great write-up without all of the technical detail; also not behind a
paywall! Here is our paper! Find Benjamin Bratton \textbar{} Twitter
\textbar{} Google Scholar Find Thomas Bartlett \textbar{} Twitter
\textbar{} Google Scholar EDIT 1: Aaaaaaaaaaaaand we're live! Thanks for
all of the attention and great questions! We'll do our best to answer
them all. EDIT 2: Okay, we are going to call it (for now, anyway)!
Thanks for all of the great questions (and answers). We will do our best
to get to the rest of the unanswered questions at a later date.%
\end{abstract}%



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