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\begin{document}
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\title{Science AMA Series: Hi Reddit! I'm Olivier George from The Scripps
Research Institute, here to answer your questions about how drugs and
alcohol affect our neural networks! Ask Me Anything!}



\author[1]{Olivier_George }%
\author[1]{r/Science AMAs}%
\affil[1]{Affiliation not available}%


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  \date{April 24, 2026}


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\begin{abstract}
Hi Reddit! I'm Olivier George, principal investigator at The Scripps
Research Institute and member of the Committee On The Neurobiology Of
Addictive Disorders here. My lab recently published a novel study in The
Journal of Neuroscience identifying a neuronal network that may be
critical for alcoholism. This preclinical study demonstrates that the
behaviors associated with alcohol dependence may be reversed by
performing a single pharmacogenetic intervention in the brain. The
results of this study show that in rats that were heavily dependent on
alcohol, both the compulsive alcohol drinking and the physical signs of
withdrawal could be reversed back to normal by inactivating a specific
neuronal ensemble in a brain region called the central nucleus of the
amygdala. A key result in this study is the very long-lasting reversal
of alcohol dependence (\textgreater{} 2 weeks) after a single brain
manipulation, suggesting that we could use this neuronal network to
identify new molecular targets and better medications for the treatment
of alcoholism. Our lab is currently working on identifying the brain
regions under the control of this neuronal network and on identifying
new molecular targets in this network that could be used for medication
development. Curious about how addiction works and how alcohol and drugs
affect our neural networks? You can also follow our lab on Twitter Read
the press release on our research here ** I will be answering your
questions at 5pm EST (2pm PST) -- Ask Me Anything!**%
\end{abstract}%



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