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\title{Science AMA series: I co-founded two companies focused on rare and
neglected diseases, I'm Sean Ekins, Ask Me Anything!}



\author[1]{Sean_Ekins }%
\author[1]{r/Science AMAs}%
\affil[1]{Affiliation not available}%


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  \date{April 24, 2026}


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\begin{abstract}
Hi Reddit, I am currently CSO of Collaborative Drug Discovery, CEO of
Phoenix Nest, CEO of Collaborations Pharmaceuticals, Inc and CSO of the
Hereditary Neuropathy Foundation and I am on the Editorial Board of
Pharmaceutical Research. I am a graduate (MSc, PhD, DSc) of the
University of Aberdeen. I have spent 20 years working in the USA, first
as a postdoc at Eli Lilly, then as a senior scientist at Pfizer and
Lilly before joining smaller start-up companies. I then went on to
co-found and found two rare and neglected disease companies. My
background is in clinical pharmacology, with an interest in
understanding drug-drug reactions and toxicology. I quickly moved from
doing bench work to learning how to use computational approaches to make
predictions that could help drug discovery. Over the years I have
collaborated with different academics and companies to build models that
help predict how compounds bind to enzymes, transporters, ion channels
and receptors. As the datasets have grown I have applied different
machine learning approaches. My work in the last 8 years has brought me
into working on neglected diseases like tuberculosis and rare diseases
such as Sanfilippo syndrome and Charcot-Marie-Tooth disease. Again
collaborations are central to what I do. Virtually everything I work on
is funded by a grant whether from the NIH, EU or others so even though I
am not working in a university I am constantly working on small business
or other grants. Most recently my work has led to projects and
collaborations on the Ebola and Zika viruses. All of this has been
published openly and I am an advocate of open access publishing as well
as using social media to publicize science. I believe it's important for
scientists to use tools like Twitter to tell the world about their work,
conferences they are attending and publications. I will be back at 11 am
ET (8 am PT) to answer your questions on rare diseases, science
collaborations, and my experience doing science outside of academia.%
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