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\title{Science AMA Series: We're scientists and doctors researching nano
medicine, Ask Us Anything!}



\author[1]{nanomedicines }%
\author[1]{r/Science AMAs}%
\affil[1]{Affiliation not available}%


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  \date{April 24, 2026}


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\begin{abstract}
Hi Reddit we are scientists from Toronto/Boston working on improving the
use of nanomedicine in the clinic. If you're curious about our list of
credentials: Shawn Stapleton PhD, Research Fellow at Harvard Medical
School/Massachusetts General Hospital, who's currently looking to
transition into faculty.
https://www.researchgate.net/profile/Shawn\_Stapleton
https://www.linkedin.com/in/staplet David Jaffray PhD, Senior Scientist
and Director of the TECHNA Institute, University Health Network and
University of Toronto.
https://www.uhnresearch.ca/researcher/david-jaffray
http://technainstitute.com/people/david-jaffray/ Michael Milosevic MD,
Clinician and Scientist, University of Toronto and Princess Margaret
Cancer Center. https://www.uhnresearch.ca/researcher/michael-f-milosevic
http://www.radonc.utoronto.ca/content/michael-milosevic Our
collaborative research focuses on using imaging, mathematical modeling
and physiological/molecular measurements of the tumor microenvironment
to understand where nanomedicines end up in a tumour. We are using this
knownledge to (1) develope strategies to improve nanomedicine drug
delivery to tumours; and (2) develop new clinically relevant imaging
methods to help guide drug delivery in patients. Ultimately we'd like to
be able to use imaging methods like CT, MRI, or PET to bring drug
delivery to the same level of precision achieved with radiation therapy
and surgery. We've recently published a review describing how radiation
can be used to improve nanomedicine drug delivery to tumors, leading to
improved tumor response. The manuscript, titled ``Radiation effects on
the tumor microenvironment: Implications for nanomedicine delivery. '',
can be found in Advanced Drug Delivery Reviews . Check it out!
http://www.sciencedirect.com/science/article/pii/S0169409X16301818 This
is exciting area of research that will allow us to use clinical methods,
such as radiotherapy, to guide where nanoparticles go in the tumor AND
increase local drug concentrations without increasing toxicity. We are
here to answer your questions about drug delivery, nanomedicine,
imaging, radiotherapy, oncology, the pains/pleasures of research,
transitioning to/making it in academia, why Toronto is an exciting for
biomedical research, and more! Ask US Anything!%
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