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\title{ACS AMA: Hi Reddit! My name is Dr. John M Newsam CEO of Tioga Research,
Inc. Ask me anything about the skin or materials applied to the skin, or
about founding and building a small company.}



\author[1]{AmerChemSocietyAMA }%
\author[1]{r/Science AMAs}%
\affil[1]{Affiliation not available}%


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  \date{April 23, 2026}


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\begin{abstract}
Hi Reddit! I'm Dr. John M. Newsam and I serve as CEO of Tioga Research
is a contract research organization (``CRO''). Our specialty is
formulations applied to the skin. We undertake research and early
development programs for pharmaceutical, cosmetic \& personal care, and
medical device clients. We have particular expertise in formulations
innovation and in screening skin permeation and delivery. We use
proprietary high throughput experimentation (``HTE'') platforms to
increase the efficiency with which we can screen formulations for their
ability to enhance delivery of an active molecule into and through the
skin. We work with a spectrum of companies, in the US and also in
Europe, Japan, India and beyond, and we help these clients in a broad
range of R\&D projects. I am a chemist, a materials chemist by training.
After my BA, MA and DPhil degrees in Oxford I spent nearly two years
doing neutron scattering research in the Physics Department of Tohoku
University in Japan. Deciding then to come to the US, I had to decide
first between an academic or industrial track. Choosing the latter, I
joined ExxonMobil Corporate Research in New Jersey, where I was
fortunate to be able to work on inorganic materials for a range of
interesting applications, including ceramics, catalysts, zeolites, and
oxide superconductors. I got interested in computer simulation and was
then recruited by Biosym Technologies, a molecular simulation software
company in San Diego. I had various executive roles, including Chief
Scientific Officer, as the company was acquired by Corning, merged with
Molecular Simulation, and was acquired by Pharmacopeia (now Biovia DS).
I then became more interested in start-up and early phase companies,
co-founding FreedomVoice Systems, hte AG, fqubed, Integrated Discovery
Sciences, Bio4Front and, in 2011, Tioga Research. I also serve as an ACS
Expert an AAAS Fellow and a RSC Fellow; I enjoy teaching
entrepreneurship to undergraduates at UCSD and discussing with local
middle- and high-schoolers interested in chemistry. I will be back at 1
pm EST to answer your questions, so, ask me anything about the skin and
materials applied to the skin. You can also ask me about my research
background, and anything about founding, building, and experiences
working for a small company. I need to leave again - but as there are so
many questions I was not able to get to, I will work to schedule some
time tomorrow to field a few more. Thank you again for your interest. I
am back online to field some more questions (although I have realized
that some of my earlier responses were apparently not posted as a result
of my internet access issues - I will try to re-answer) Apologies - we
have apparently had an internet outage, so my replies and comments have
been delayed; I'm still online Good morning (at least in California
time) . . . I am now online to answer any questions you might have.
Apologies - we have apparently had an internet outage, so my replies and
comments have been delayed; I'm still online Wow - so many interesting
questions and comments. Thank you. I have to leave now due to other
commitments, but I'll try to connect again later in the day to field a
few more questions. I have enjoyed the dialog with each of you, even for
you that asked questions that I haven't gotten to. Many thanks for your
interest. Please check out www.tiogaresearch.com for more information,
if you are interested. Video produced by ACS released 11/15/16 on acne
https://www.youtube.com/watch?v=KrMbwDil1hc -ACS edit%
\end{abstract}%



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