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\title{ACS AMA: I am Wilfredo ``Freddy'' Colon, Ph.D., a professor at
Rensselaer Polytechnic Institute who researches the biology and
pathology of misfolding proteins. Ask me anything about prions or
brain-affecting protein-based diseases.}



\author[1]{AmerChemSocietyAMA }%
\author[1]{r/Science AMAs}%
\affil[1]{Affiliation not available}%


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  \date{April 23, 2026}


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\begin{abstract}
Hi Reddit! I'm Dr. Wilfredo Colon. Call me Freddy. I'm a Professor and
the Chair in the Department of Chemistry and Chemical Biology,
Rensselaer Polytechnic Institute (http://rpi.edu) in Troy, NY. I
research the biological and pathological roles of protein hyperstability
in protein function, misfolding and amyloid formation. Proteins in our
bodies are marginally stable, allowing us to repair and replace older
proteins with new identical ones. As we age, our bodies become less
efficient at this degradation process, and proteins can misfold and
aggregate, leading to problems associated with aging (e.g., Alzheimer's,
Parkinson's, cancers). Hyperstable protein aggregates are too stable to
degrade, interfering with cellular function and are thought to
contribute to complications with aging and disease. A long-term goal of
my research is to understand the role of protein hyperstability in
biological adaptation, aging, and diseases. To that end, I've developed
methods for discovering and analyzing protein hyperstability in
biological fluids or tissue. I am a first-generation Hispanic college
student who went into science in academia. I've had various roles over
the years including a National Science Foundation (www.nsf.gov) program
director, a director of education and outreach programs, and my current
role as a professor. I got a B.S. in chemistry from the University of
Puerto Rico at Mayag\selectlanguage{ngerman}üez (www.uprm.edu/ ) and a Ph.D. in chemistry from
Texas A\&M University (www.tamu.edu). I am an ACS Expert, an AAAS
Fellow, and I've been honored to receive a Presidential Early Career
Award in Science and Engineering. **Hi everyone. This hour went by too
fast. Thank you for your questions and interest on this topic. I had a
great time and wish I had been able to answer more of your questions. I
apologize if I did not get to your question. Perhaps I could come back
in the near future for another session. -acs affiliation correction and
style edits%
\end{abstract}\selectlanguage{ngerman}%



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