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\title{American Chemical Society AMA: I am M.G. Finn, Editor-in-Chief of ACS
Combinatorial Science, here to discuss why combi chem is not dead. Ask
me anything!}



\author[1]{AmerChemSocietyAMA }%
\author[1]{r/Science AMAs}%
\affil[1]{Affiliation not available}%


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  \date{April 23, 2026}


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\begin{abstract}
Welcome! I am M.G. Finn, Editor-in-Chief of ACS Combinatorial Science.
My group does research in a variety of areas that seek to develop
molecular function, but we define ``molecular'' in ways that go from
small molecule drugs to large multiprotein assemblies to organisms. In
particular, we develop and optimize reactions for bioconjugation and
release, engineer virus-like nanoparticles for immunology, cell
targeting, and enzyme encapsulation, and work on new ways to evolve
aptamers and enzymes. Since moving to Georgia Tech in 2013, we are also
doing a lot more materials science, trying to apply some of our click
chemistry techniques and attitudes to the creation of new functional
polymers and surfaces. An appreciation for molecular function is what
motivated me to steer the journal into expanded waters, while retaining
a core commitment to the publication of good synthetic chemistry. ACS
Comb. Sci. now publishes papers in a wide variety of areas in which
functional structures are made, identified, or enhanced by combinatorial
means. We also like to highlight methods --- synthetic, analytical, and
theoretical --- by which function can be created and measured.
Combinatorial biology, materials development, and drug development are
all combinatorial chemistry in my view, and so the field is most
certainly very much alive. Thanks VERY much to everyone who posted
questions and comments - I had a great time and you gave me some good
things to think about. (Hopefully, that feeling is mutual.) I look
forward to the next AMA.%
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