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\title{PLOS Science Wednesday: Hi reddit we're Graham and Richard, and we
identified the molecular mechanism that creates genetic variations
associated with increased risk of autoimmune diseases, such as celiac,
ulcerative colitis etc. -- Ask Us Anything!}



\author[1]{PLOSScienceWednesday }%
\author[1]{r/Science AMAs}%
\affil[1]{Affiliation not available}%


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  \date{April 23, 2026}


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\begin{abstract}
Hi Reddit, My name is Graham Lord and I am the Professor of Medicine at
King's College London. My research focuses on understanding the cellular
and molecular mechanisms that cause inflammatory bowel diseases. And my
name is Richard Jenner and I am a Reader (Associate Professor) in
Molecular Biology at University College London (UCL). My research
focuses on understanding how gene transcription and chromatin
modification regulate immune cell function in health and disease. We
recently published a paper titled ``Genetic variants alter T-bet binding
and gene expression in mucosal inflammatory disease'' in PLOS Genetics.
We found that the transcription factor, T-bet bound to genetic variants
associated with human mucosal inflammatory diseases, such as celiac
disease, Crohn's disease and ulcerative colitis. We also developed a new
technique called ``OligoFlow'' that allowed us to identify altered
transcription factor binding to these variants. We will be answering
your questions at 1pm ET -- Ask Us Anything! Click here for more
information about Dr. Jenner's lab.%
\end{abstract}%



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