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\title{PLOS Science Wednesday: Hi reddit, we're Johannes and Katja, and our
research investigates the molecular processes that help chlamydiae
pathogenic bacteria infect human hosts -- Ask us Anything!}



\author[1]{PLOSScienceWednesday }%
\author[1]{r/Science AMAs}%
\affil[1]{Affiliation not available}%


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  \date{April 23, 2026}


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\selectlanguage{english}
\begin{abstract}
Hi Reddit, My name is Johannes Hegemann and I am Professor of
Microbiology and Head of the Institute for Functional Microbial Genomics
at the Heinrich-Heine-University in D\selectlanguage{ngerman}üsseldorf, Germany. And my name in
Katja Mölleken and I am a Senior Postdoctoral Fellow at the Institute
for Functional Microbial Genomics at the Heinrich-Heine-University in
Düsseldorf, Germany. Our research focuses on the molecular mechanisms
that enable the pathogenic bacteria Chlamydia trachomatis and Chlamydia
pneumoniae to infect their human hosts. This month, we published a study
titled ``Acquisition of Rab11 and Rab11-Fip2 -- A novel strategy for
Chlamydia pneumoniae early survival'' in the journal PLOS Pathogens.
Infection begins when the chlamydiae recognize specific receptors on
their target cells, which triggers uptake of the bacteria. Once inside
the cell, they establish a membrane-bound compartment termed an
inclusion, in which they multiply before being released to infect new
human cells. In our study we found that the nascent chlamydial inclusion
actively recruits specific host proteins called Rab proteins into its
membrane. These proteins define the inclusion as a so-called recycling
endosome vesicle, within which the Chlamydiae hide out, so as to avoid
degradation by the host cell's waste disposal system, the lysosome. Our
findings help to understand how Chlamydiae establish the intracellular
niche which is essential for their survival and release. We will be
answering your questions at 1pm ET -- Ask us Anything!%
\end{abstract}\selectlanguage{ngerman}%



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