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\title{PLOS Science Wednesday: Hi reddit, I'm Ronnie Sebro and my study in PLOS
Genetics is the first multi-generational analysis of mating patterns in
the US -- Ask Me Anything!}



\author[1]{PLOSScienceWednesday }%
\author[1]{r/Science AMAs}%
\affil[1]{Affiliation not available}%


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  \date{April 23, 2026}


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\begin{abstract}
Hi Reddit, My name is Ronnie Sebro and I am an Assistant Professor in
Genetics and Radiology at the University of Pennsylvania. As a
statistical geneticist and radiologist, my research interests center
around genetic analysis of quantitative imaging phenotypes. More
recently, I have been exploring the impact of non-random mating on
genetic association studies. I recently published a study ``Structured
mating: Patterns and implications'' in PLOS Genetics in conjunction with
collaborators at the University of California, San Francisco and Boston
University School of Public Health. The aim of the study was to assess
how the mating patterns in a European-American population changed over
time (over 3 generations, starting in 1948) and to discuss the
implication of these findings for current genetic studies. We found
there were primarily three clusters of individuals -- those with
Northern/European ancestry, those with Southern European ancestry and
those with Ashkenazi Jewish ancestry. In the first generation, we found
that individuals were more likely to choose spouses with similar genetic
ancestry (i.e. from the same cluster), however the strength of this
association decreased with each successive generation, suggesting
gradual intermixing between clusters. Some of the physical and
behavioral similarities seen between spouses may be as a result of their
similar genetic ancestry. I will be answering your questions at 1pm ET
-- Ask me Anything!%
\end{abstract}%



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