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\title{PLOS Science Wednesday: Hi reddit, we're Marinho and Leandro and we
applied math models to explore the brain regions that contribute most to
seizures to help neurosurgeons perform more targeted surgeries for
epilepsy patients -- Ask Us Anything!}



\author[1]{PLOSScienceWednesday }%
\author[1]{r/Science AMAs}%
\affil[1]{Affiliation not available}%


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  \date{April 24, 2026}


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\begin{abstract}
Hi Reddit, My name is Marinho Lopes and I am a Research Fellow at the
University of Exeter. And I'm Leandro Junges and I am a Research Fellow
at the EPSRC centre for predictive modelling in healthcare at the
University of Exeter. Our research focuses on the mechanisms of seizure
emergence and on mathematical models to quantitatively predict whose
brains regions are most responsible for seizure generation. Our group
recently published a paper titled ``An optimal strategy for epilepsy
surgery: Disruption of the rich-club?'' in PLOS Computational Biology.
We used statistical methods to determine how different regions were
connected from the electrical recordings of the brain. We then applied
advanced mathematical modelling to study which regions of the brain
contribute most greatly to generating seizures and whether their removal
would result in the brain being seizure-free. The idea being that if
brain surgeons targeted these regions the outcome of surgery would be
enhanced. We will be answering your questions at 1pm ET-- Ask Us
Anything! Don't forget to follow our group on Twitter @CBMA\_UoE.%
\end{abstract}%



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