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\begin{document}
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\title{PLOS Science Wednesday: Hi reddit, I'm Ole Andreassen and my colleagues
and I developed and validated a new genetic score to predict the age of
Alzheimer's disease onset -- Ask Me Anything!}



\author[1]{PLOSScienceWednesday }%
\author[1]{r/Science AMAs}%
\affil[1]{Affiliation not available}%


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  \date{April 24, 2026}


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\begin{abstract}
Hi Reddit, My name is Ole Andreassen and I am a Professor in Psychiatry
at University of Oslo. I have also a clinical position where I see
patients regularly in the outpatient clinic at Oslo University Hospital.
My research focuses on severe mental illness and neurodegenerative
diseases. We recently published an article titled Genetic assessment of
age-associated Alzheimer's disease risk: development and validation of a
polygenic hazard score in PLOS Medicine. In this paper, we describe the
development and validation of a new genetic score to predict Alzheimer's
disease age of onset. Our results show that genetic data can be combined
with epidemiological information on dementia incidence rates from the US
population to derive a score that can predict age-specific risk for
Alzheimer's disease. I'll be answering questions at 1pm ET -- Ask Me
Anything!%
\end{abstract}%



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