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\title{PLOS Science Wednesday: Hi Reddit, my name is Scott Hensley and I
recently published a study showing that antibodies with the ``original
antigenic sin'' phenotype are an important component of immune responses
against influenza -- Ask Me Anything!}



\author[1]{PLOSScienceWednesday }%
\author[1]{r/Science AMAs}%
\affil[1]{Affiliation not available}%


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  \date{April 24, 2026}


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\begin{abstract}
Hi Reddit, My name is Scott Hensley and I am an Associate Professor at
the University of Pennsylvania. My research focuses on how our immune
systems try to stop pathogens and how pathogens fight back. At our lab,
we are particularly interested in figuring out how viruses evade
antibody responses. We recently published a study titled `Antibodies
with Original Antigenic Sin Properties Are Valuable Components of
Secondary Immune Responses to Influenza Viruses' in PLOS Pathogens. In
this study, we used a mouse model to show that antibodies stimulated by
past influenza virus infections can help fight against new antigenically
distinct influenza viruses, despite binding poorly to these new viruses.
We propose that these antibodies, classically termed `original antigenic
sin' antibodies, are an important component of secondary immune
responses against influenza viruses. I will be answering your questions
at 1pm ET -- Ask Me Anything! Don't forget to follow our lab on Twitter
@SCOTTeHENSLEY.%
\end{abstract}%



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