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\title{Hi Reddit, we're Malcolm MacLeod and David Howells, and we published a
paper in PLOS Biology that found an elevated average risk of bias in
work from leading institutions or work published in high-impact factor
journals -- Ask Us Anything!}



\author[1]{PLOSScienceWednesday }%
\author[1]{r/Science AMAs}%
\affil[1]{Affiliation not available}%


\vspace{-1em}



  
  \date{April 24, 2026}


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\begin{abstract}
Hi Reddit, My name is Malcolm Macleod and I am Professor of Neurology
and Translational Neuroscience at the University of Edinburgh. I'm
interested in risks of bias in animal research, and how these might get
in the way of the development of new drugs. And my name is David Howells
and I am Professor of Neuroscience and Brain Plasticity at the
University of Tasmania. My research on stroke focuses on how we
translate good ideas into solid bench science that might then survive
the rigor of clinical trialing to provide treatments for brain diseases.
We recently published a study titled ``Risks of bias in reports of in
vivo research: A focus for improvement'' in PLOS Biology. This study
extends work across multiple neuroscience domains which highlights the
risk of overestimation of the potential for translational success when
studies fail to take measures to reduce the impact of bias. This study
investigated whether this held true across a broader range of science
and whether where the work was conducted or published influenced the
risk of bias. We already know that publications which do not describe
certain design features which reduce the risk of bias (e.g.
randomization, blinding) tend to exaggerate observed effects, at least
in the neurosciences. We were interested to see whether this was the
case more generally, and if this was different in journals with a high
impact factor or in work from leading institutions. We found that nobody
is doing particularly well but also that work from leading institutions
or published in high impact factor journals was at greater than average
risk of bias. We hope that scientists, institutions, journals, and
funders will use these findings to help improve the process of drug
discovery and development. We will be answering your questions at 1pm
EST (10am PST and 5am on 1/14/16 in Melbourne). Ask Us Anything! You can
follow Malcolm on Twitter @maclomaclee, and @CAMARADES\_%
\end{abstract}%



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